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Tratamento neoadjuvante do cancro do reto

Tratamento neoadjuvante do cancro do reto

Dhouha Bacha / Malek Jedidi

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Medicina: cuestiones generales
ISBN:
9786208468422
65,61 €
IVA incluido
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Sobre IBD

Objetivo: O objetivo deste estudo foi investigar os factores preditivos da resistência ao tratamento neoadjuvante da RC localmente avançada em doentes tunisinos.Métodos: Estudo retrospetivo de doentes com RC operados após radioquimioterapia neoadjuvante (RCT). A FC foi avaliada de acordo com o TRG de Dworak, cujos cinco graus foram posteriormente agrupados em duas categorias: Grupo de Resposta (R) para TRG3 e 4 e Grupo Sem Resposta (PR) para TRG 0, 1 e 2.Resultados: O estudo incluiu 88 doentes com uma idade média de 60 anos. O local da RC foi o reto médio em 63% dos casos. A invasão de nódulos foi registada em 52 doentes (59%). O grupo R foi constituído por 29 doentes (33%) e o grupo PR por 59 doentes (67%). Na análise multivariada, os factores preditivos para a RH foram a idade ≤ 60 anos, o sexo masculino e a infiltração parietal pré-terapêutica de cT3.Conclusão: No CC localmente avançado, os pacientes com idade ≤ 60 anos, do sexo masculino, com infiltração parietal cT3 pré-terapêutica, seriam os melhores candidatos para uma estratégia de RCT neoadjuvante seguida de excisão cirúrgica.

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