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Transizione epitelio-mesenchimale

Transizione epitelio-mesenchimale

Deepu George Mathew / Priya Thomas / Sonu Raju

65,49 €
IVA incluido
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Música
ISBN:
9786209357541
65,49 €
IVA incluido
Disponible

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La transizione epiteliale-mesenchimale (EMT) rappresenta un processo biologico fondamentale in cui le cellule epiteliali perdono la loro polarità caratteristica, l’adesione intercellulare e l’architettura organizzata, acquisendo un fenotipo mesenchimale caratterizzato da maggiore motilità, invasività e resistenza all’apoptosi. Questo evento di riprogrammazione cellulare reversibile svolge un ruolo cruciale nello sviluppo embrionale, nella rigenerazione dei tessuti, nella fibrosi e nella progressione del cancro. Negli ultimi decenni, l’EMT è emersa come un paradigma fondamentale nella biologia cellulare e nella patologia, collegando i processi di sviluppo e i meccanismi patologici attraverso la regolazione della plasticità cellulare. La comprensione delle dinamiche molecolari, cellulari e di segnalazione dell’EMT è quindi diventata essenziale per comprendere un ampio spettro di fenomeni fisiologici e patologici. Nell’embriogenesi, l’EMT governa eventi morfogenetici chiave come la gastrulazione, la formazione della cresta neurale e lo sviluppo degli organi. La conversione transitoria e strettamente regolata delle cellule epiteliali in cellule mesenchimali migratorie facilita il rimodellamento dei tessuti e la strutturazione spaziale necessari per la formazione di complesse strutture multicellulari.

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