Therapeutic Targets of the TNF Superfamily

1. Overview of TNF Superfamily: A Chest Full of Potential Therapeutic TargetsIqbal S. Grewal Abstract Introduction Therapeutic Potential of TNF Superfamily for Anticancer Treatment Therapeutic Potential of TNF Superfamily for Autoimmune and Inflammatory Disease Challenges for Targeting TNF Superfamily Members Summary and Conclusions 2. Therapeutic Interventions Targeting CD40L (CD154) and CD40: The Opportunities and ChallengesChe-Leung Law and Iqbal S. Grewal Abstract Introduction CD40L Expression in Autoimmune and Inflammatory Conditions CD40-Mediated Inflammatory Reaction Genetic Evidence for the Contribution of CD40-CD40L Interaction in Experimental Autoimmune and Inflammatory Diseases Therapeutic Targeting of CD40L: Proof of Concept Preclinical Animal Models of Autoimmunity and Inflammation Clinical Experience with Anti-CD40L Mechanism(s) of Action of Anti-CD40L mAbs: Toxicity versus Efficacy Potential Alternative Therapeutic Approaches Targeting CD40L CD40 Signaling in Transformed Cells CD40 and Cancer Immune Surveillance Characteristics of Anti-CD40 Antibodies Clinical Experience in Therapeutic Targeting of CD40 Considerations for Therapeutics Targeting CD40 Conclusions 3. Targeting TNF for Treatment of Cancer and AutoimmunityGautam Sethi, Bokyung Sung, Ajaikumar B. Kunnumakkara and Bharat B. Aggarwal Abstract Discovery of TNF Signaling Mechanism(s) by TNF-a Role of TNF-a in Cancer Role of TNF-a in the Immune System Role of TNF-a in Autoimmune Diseases TNF Inhibitors Natural Products as Inhibitors of TNF Conclusion 4. Targeting of BAFF and APRIL for Autoimmunity and OncologyMaureen C. Ryan and Iqbal S. Grewal Abstract Introduction The BAFF and APRIL Receptor/Ligand System BAFF and APRIL Regulate Immune Functions BAFF and APRIL in Autoimmunity APRIL and BAFF in Cancer Parallels between Autoimmunity and Cancer New Therapeutics for Autoimmunity and Cancer Future Applications, New Research, Anticipated Developments 5. The Role of FasL and Fas in Health and DiseaseMartin Ehrenschwender and Harald Wajant Abstract The FasL-Fas System The FasL-Fas System in Health and Disease Therapeutic Concepts Targeting the FasL-Fas System 6. OX40 (CD134) and OX40LMichael J. Gough and Andrew D. Weinberg Abstract Expression of OX40 and OX40L Biologic Function of OX40-OX40L Interactions Expression and Role of OX40 and OX40L in Disease Intervention in OX40-OX40L Interaction for Therapy Conclusion 7. Targeting CD70 for Human Therapeutic UseTamar Boursalian, Julie McEarchern, Che-Leung Law and Iqbal S. Grewal Abstract Introduction CD70 Expression and Biology CD70 in Autoimmunity CD70 in Oncology Conclusions and Future Directions 8. 4-1BB as a Therapeutic Target for Human DiseaseSeung-Woo Lee and Michael Croft Abstract Introduction to Basic Research Expression of 4-1BB and 4-1BBL Therapeutic Effects of Targeting 4-1BB or 4-1BBL Possible Mechanisms of Action of 4-1BB Agonistic Antibodies Concluding Remarks 9. RANK(L) as a Key Target for Controlling Bone LossAndreas Leibbrandt and Josef M. Penninger Abstract Overview Basic Characteristics of the RANKL-RANK-OPG Axis Bone Remodeling and the RANKL-RANK-OPG Axis RANK(L) Signaling Pathways RANK(L) Signaling in the Immune System<