Proton Pump Inhibitors

Proton Pump Inhibitors

Lars Olbe

245,50 €
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Editorial:
Springer Nature B.V.
Año de edición:
1999
Materia
Medicina: cuestiones generales
ISBN:
9783764358976

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The discovery and development of the proton pump inhibitor.- The discovery and development of the proton pump inhibitor.- Mechanism of action.- The gastric H, K ATPase.- Inhibition of the gastric proton pump.- The Pharmacology of proton pump inhibitors.- Inhibition of gastric acid secretion.- Consequences of gastric acid inihibition in animals.- Consequences of gastric acid inhibition in man.- The acid tolerance of Helicobacter pylori.- Interactions of proton pump inhibitors and Helicobacter pylori in vivo.- Comparison of different proton pump inhibitors.- Pharmaceutical considerations.- Pharmaceutical considerations.- Clinical experience with proton pump inhibitors.- Helicobacter pylori infection and peptic ulcer disease.- Non-steroidal anti-inflammatory drug-associated ulcers.- Zollinger-Ellison syndrome.- Gastro-oesophageal reflux disease.- Socio-Economic impact of acid-related diseases.- Socio-economic impact of acid-related diseases.

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    Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi­ bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specifi...
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