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Post‑Transcriptional Regulation by STAR Proteins

Post‑Transcriptional Regulation by STAR Proteins

 

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Editorial:
Springer Nature B.V.
Año de edición:
2016
Materia
Neurología y neurofisiología clínicas
ISBN:
9781489978059
276,93 €
IVA incluido
Disponible

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1. STAR TREK: An Introduction to STAR Family Proteins and Review of QKIKaren Artzt and Jiang I. WuAbstractHistory of the STAR FamilyThe Domain Structure and Alternate Splicing of STAR ProteinsSTAR Proteins Have a Multitude of Developmental FunctionsDiverse Molecular Functions of STAR Proteins in RNA ProcessingQk Expression in the Adult Nervous System and DiseaseQk 3? UTR Conservation and a High Theoretical Number of miRNA Binding SitesDiscussion and ConclusionFuture Applications, New Research, Anticipated Developments2. THE STAR FAMILY MEMBER: QUAKING (QKI) AND CEL SIGNALINGYue Feng and Andrew BankstonAbstractIntroductionQKI Is Essential for Embryonic and Postnatal DevelopmentPhosphorylation of QKI Isoforms by Src?PTKS Regulates the Cellular Fate of QKI mRNA Targets at Multiple Post?Transcriptional StepsNumerous Extracellular Signals Can Be Linked to the Src?PTK?QKI PathwayPotential Role of QKI And Src?PTK Signaling in Tumorigenesis and Cognitive DiseasesConclusion3. INSIGHTS INTO THE STRUCTURAL BASIS OF RNA RECOGNITION BY STAR DOMAIN PROTEINSSean P. Ryder and Francesca MassiAbstractIntroductionThe STAR DomainRNA Recognition By STAR ProteinsStar Domain StructureConclusionNote Added in Proof4. Post?translat ional Regulat ion of STAR Proteins and Effects on Their Biological FunctionsClaudio SetteAbstractIntroductionSam68: A Brief OverviewRegulation of Sam68 Functions by Tyrosine PhosphorylationRegulation of Sam68 Functions by Serine/Threonine PhosphorylationRegulation of Sam68 Functions by MethylationRegulation of Sam68 Functions by Acetylation and SumoylationPost?Translational Modifications of SLM?1 and SLM?2Post?Translational Modifications of the QKI ProteinsPost?Translational Modifications of SF1Conclusion5. EXPRESSION AND FUNCTIONS OF THE star PROTEINS Sam68 AND t?star IN MAMMALIAN SPERMATOGENESISIngrid Ehrmann and David J. ElliottAbstractGene Expression Control in SpermatogenesisExpression ofSTAR Proteins during SpermatogenesisProtein Structure and ModificationsMouse Knockout Models Define the Roles of STAR Proteins in Testis FunctionThe STAR Protein Sam68 Is Involved in Translational Control in SpermatogenesisSTAR Proteins Might Play Roles in Pre?mRNA Splicing Control in SpermatogenesisOther Potential Roles of STAR Proteins in SpermatogenesisConclusion6. The role of quaking in mammalian embryonic developmentMonica J. Justice and Karen K. HirschiAbstractIntroductionQuaking Is Required for the Formation of Embryonic VasculatureQKI5 Regulates QKI6 and QKI7 in Visceral EndodermMolecular Basis of Blood Vessel FormationQuaking Is Required for Visceral Endoderm Differentiated FunctionOther Possible Roles for Quaking in Cardiovascular DevelopmentThe Evolving Roles of Quaking FunctionConclusion7. Drosophila STAR Proteins: What Can Be Learned from Flies?Talila VolkAbstractSTAR Proteins in DrosophilaHOW Regulates Differentiation of Diverse TissuesHOW and Kep1 Regulate Cell Division and Apoptosis in DrosophilaConclusionNote Added in Proof8. C. ELEGANS STAR PROTEINS, GLD?1 AND ASD?2, REGULATE SPECIFIC RNA TARGETS TO CONTROL DEVELOPMENTMin?Ho Lee and Tim SchedlAbstractMultiple Functions of GLD?1 in Germline DevelopmentGLD?1 Molecular AnalysismRNA Targets: GLD?1 Is a Translational RepressormRNA Targets: Further Insights into GLD?1 Function in Germline DevelopmentmRNA Targets: Towards Defining the GLD?1 RNA Binding Motif and Mechanism of Translational RepressionHow Is GLD?1 Expression Regulated?ASD?2, Another C. elegans Star Protein, Functions in Alternative SplicingConclusion9. THE BRANCHPOINT BINDING PROTEIN: In and Out of the Spliceosome CycleBrian C. RymondAbstractBbp and Sf1 Are Site?Specific Rna Binding ProteinsA Bbp?Mud2 Heterodimer Functions in Branchpoint RecognitionBbp?Mud2 and the Dynamics of Early Spliceosome AssemblyCo?Transcriptional Pre?mRNA SplicingBut Is Bbp Really an

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