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Определение лоратадина, метил- и пропилпарабена в антигистаминных препаратах

Определение лоратадина, метил- и пропилпарабена в антигистаминных препаратах

Абдул Шакур / Алам Шахзад / Пхул Шахзади

43,82 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Química
ISBN:
9786207935871
43,82 €
IVA incluido
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Sobre IBD

Разработан и проверен точный, простой, воспроизводимый и чувствительный метод высокоэффективной жидкостной хроматографии (HPLC SHIMADZU JAPAN FABRICATED) для одновременного определения лоратадина, метилпарабена и пропилпарабена из суспензии лоратадина для фармацевтической рецептуры. Линейные диапазоны были определены как (r2 = 0,9983) для лоратадина, (r2 = 0,9702) для метилпарабена и (r2 = 0,9985) для пропилпарабена. Процентное относительное стандартное отклонение для точности и прецизионности не превышало 2,0%. Таким образом, определение точности проводилось на трех однородных образцах в течение 72 часов. Прецизионность была выполнена на однородных образцах тремя разными исследователями в один день с использованием одной и той же подвижной фазы. УФ-детектирование (SPD-10A) 254 нм. Данный метод может быть успешно применен для рутинного анализа лоратадина, метилпарабена и пропилпарабена в различных лекарственных формах. Используемый метод является линейным, воспроизводимым, точным и надежным.

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