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Синтез и оценка новых производных карбазола

Синтез и оценка новых производных карбазола

Арчита Тивари / Бхарат Мишра / Суджит Гупта

54,12 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Química
ISBN:
9786207951604
54,12 €
IVA incluido
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Sobre IBD

Синтезирована новая серия замещенных производных карбазола. На первом этапе 2-Хлор-9-H-карбазол-3-карбальдегид образуется по реакции Вильсмайера-Хака в присутствии DMF и POCl3. Промежуточный продукт, образованный с помощью реакции Вильсмайера, далее обрабатывают другим замещенным амином, чтобы получить новое производное карбазола, соединенное с замещенным амином. Структура замещенного производного карбазола была определена с помощью тонкослойной хроматографии, ИК-Фурье и ЯМР 1Н. С помощью модели максимального электрошока (МЭШ) определяли силу синтезированных соединений по уменьшению судорог в различные временные интервалы. Среди всех синтезированных соединений максимальную противосудорожную активность проявило соединение 4e. Соединение 4c и соединение 4f также продемонстрировали лучшую противосудорожную активность.

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