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Micromachined Sensors to Study Cell Mechanical Response

Micromachined Sensors to Study Cell Mechanical Response

Shengyuan Yang

60,48 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2008
Materia
Tecnología: cuestiones generales
ISBN:
9783639058574
60,48 €
IVA incluido
Disponible

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Increasing evidence has shown that living cells respond to mechanical stimuli not only mechanically but also biochemically. But how they respond to mechanical stimuli and the mechanisms through which they transduce the mechanical stimuli into biological responses re­main largely unclear.In this research, novel versatile and flexible microelectromechanical systems (MEMS) sensors were developed for studying mechanical response of single living cells. These sensors measure cell force res­ponse in the range of one nano newton to one micro newton, which is largely inaccessible for the current relevant prevalent techniques such as atomic force microscopy, optical tweezers, and magnetic twisting cytometry. These sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neu­rons, and first-time experiments and surprising findings are reported. This work enhances our current understanding and sheds new light on cellular mechanosensitivity and mechanotransduction.This book, therefore, is especially useful for researchers and engineers related to cell and tissue mechanobiology, MEMS, tissue engineering, and regenerative medicine.

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