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Enzym arginaza w akromegalii irackiej

Enzym arginaza w akromegalii irackiej

Baydaa A. Abed / Fatima Kh. Malek / Salma A. Abbas

52,01 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Química
ISBN:
9786208394516
52,01 €
IVA incluido
Disponible

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Sobre IBD

L-arginaza (EC 3.5.3.1), ostatni enzym w cyklu mocznikowym, jest dwujądrowym metaloenzymem Mn2+. Enzym katalizuje reakcję obejmującą hydrolizę L-argininy do L-ornityny i mocznika.Akromegalia (ACRO) jest rzadkim i złożonym zespołem hormonalnym klasyfikowanym jako przewlekłe zaburzenie charakteryzujące się podwyższonym poziomem hormonu wzrostu (GH), a w konsekwencji insulinopodobnego czynnika wzrostu-1 (IGF-1). Jest to zwykle spowodowane gruczolakiem przysadki wydzielającym GH, co prowadzi do wieloukładowych skutków. Wpływ ten dotyczy układu kostno-stawowego, mięśni, mózgu, serca i naczyń krwionośnych, układu oddechowego i krwiotwórczego, nerek, wątroby i trzustki, tarczycy, tkanki tłuszczowej i układu metabolicznego.Celem tego badania jest ocena poziomu aktywności arginazy, GH, IGF-1, glukozy, profilu lipidowego i mocznika w surowicy u pacjentów z ACRO z cukrzycą i bez cukrzycy. Ponadto badanie ma na celu zbadanie korelacji między arginazą a GH, glukozą i profilem lipidowym.

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