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Eficácia das terapêuticas sem acetilcolinesterase no declínio cognitivo

Eficácia das terapêuticas sem acetilcolinesterase no declínio cognitivo

Iyanuloluwa OJO / Onur ORAL

67,30 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Medicina: cuestiones generales
ISBN:
9786139748969
67,30 €
IVA incluido
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O declínio cognitivo nas populações envelhecidas, particularmente entre as pessoas diagnosticadas com défice cognitivo ligeiro (DCL) e doença de Alzheimer (DA), representa um desafio crescente para a saúde pública. Durante décadas, os inibidores da acetilcolinesterase continuaram a ser a pedra angular da intervenção farmacológica nestes grupos. No entanto, as crescentes preocupações com os seus efeitos adversos cardiovasculares e respiratórios - especialmente em doentes idosos com múltiplas comorbilidades - tornam necessária a exploração de terapêuticas alternativas com perfis mais seguros e eficácia potencialmente superior. Este trabalho apresenta os resultados de uma revisão sistemática e meta-análise com o objetivo de identificar e avaliar tratamentos não acetilcolinesterásicos para o declínio cognitivo em doentes com CCL, DA ou em indivíduos com 65 anos ou mais. Realizámos uma pesquisa rigorosa da literatura na PubMed e na Biblioteca Cochrane, abrangendo estudos publicados entre 1 de janeiro de 1990 e 30 de setembro de 2024. Os estudos elegíveis incluíram ensaios clínicos randomizados e acompanhamentos longitudinais que utilizaram avaliações neurológicas padronizadas para medir os resultados cognitivos.

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