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Drug Delivery to the Brain

Drug Delivery to the Brain

 

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Editorial:
Springer Nature B.V.
Año de edición:
2016
Materia
Medicina: cuestiones generales
ISBN:
9781493943661
248,47 €
IVA incluido
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I. PHYSIOLOGY AND BASIC PRINCIPLES FOR DRUG HANDLING BY THE BRAIN1. Anatomy and physiology of the blood-brain barriersN Joan Abbott2. Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the BrainMasanori Tachikawa, Yasuo Uchida, Sumio Ohtsuki and Tetsuya Terasaki3. Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP)Yasuo Uchida, Masanori Tachikawa, Sumio Ohtsuki And Tetsuya Terasaki4. Drug Metabolism at the Blood-Brain and Blood-CSF BarriersXavier Declèves, Nathalie Strazielle, Jean-Michel Scherrmann and Jean-François Ghersi-EgeaII. PHARMACOKINETIC CONCEPTS AND METHODS FOR STUDYING DRUG DELIVERY ACROSS THE BLOOD-BRAIN BARRIER5. Pharmacokinetic Concepts in Brain Drug DeliveryMargareta Hammarlund-Udenaes6. In vitro models of blood-brain barriersN Joan Abbott, Diana EM Dolman, Siti R Yusof and Andreas Reichel7. In situ and in vivo animal modelsQuentin Smith and Ramakrishna Samala8. Principles of PET and its Role in Understanding Drug Delivery to the BrainStina Syvänen and Roger N. Gunn9. PKPD Aspects of Brain Drug Delivery in a Translational PerspectiveElizabeth C.M. de LangeIII. INDUSTRIAL APPROACHES FOR INVESTIGATION OF POTENTIAL CENTRAL NERVOUS SYSTEM DRUGS10. Drug Discovery Methods for Studying Brain Drug Delivery and DistributionIrena Loryan and Margareta Hammarlund-Udenaes11. Prediction of Drug Exposure in the Brain from the Chemical StructureMarkus Fridén12. Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter InteractionsAndreas Reichel13. Pharmacoeconomic Considerations in CNS Drug DevelopmentDavid GrayIV. STRATEGIES FOR IMPROVED CENTRAL NERVOUS SYSTEM DRUG DELIVERY14. Intranasal Drug Delivery to the BrainJeffrey J. Lochhead and Robert G. Thorne15. Blood-To-Brain Drug Delivery using NanocarriersPieter J. Gaillard, Corine C. Visser, Marco de Boer, Chantal C.M. Appeldoorn and Jaap Rip16. Development of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNSReinhard Gabathuler17. CNS Gene Therapy Utilizing Intravenously Administered Viral VectorsAdam K. Bevan and Brian K. Kaspar18. Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or Cerebrospinal FluidKrystof Bankiewicz19. Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues)David Fortin20. Emerging Engineering Technologies for Opening the BBBElisa E. KonofagouV. BRAIN DRUG DELIVERY IN DISEASE CONDITIONS21. Disease Influence on BBB Transport in Inflammatory DisordersGeert Schenk, Gijs Kooij, Arie Reijerkerk and Helga de Vries22. Disease Influence on BBB Transport in Neurodegenerative DisordersElizabeth C.M. de Lange23. Drug Delivery in the Context of Stroke and Brain TraumaRichard F. Keep, Jianming Xiang, Ningna Zhou and Anuska V. Andjelkovic24. Which Drug or Drug Delivery Method can change Clinical Practice for Brain Tumor Therapy?Tali SiegalAppending - Primer on Central Nervous System Structure / Function and the Vasculature, Ventricular System and Fluids of the Brain. Robert Thorne

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