Chirurgisches Forum’80

Chirurgisches Forum’80

 

84,39 €
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Editorial:
Springer Nature B.V.
Año de edición:
1980
Materia
Patología
ISBN:
9783540100355
84,39 €
IVA incluido
Disponible

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22 polytraumatisierte und septische Patienten einer Intensiv­ station wurden im Rahmen einer Doppelblindstudie mit Pirenzepin bzw. Placebo behandelt. Alle Patienten wurden wahrend des Beob­ achtungszeitraumes in 14 Tagen dreimal endoskopiert. Ohne Pro­ phylaxe waren 100% StreB-Lasionen zu beobachten, 60% wiesen Blu­ tungen auf. Eine prophylaktische, intravenose Pirenzepin-Gabe hatte einen eindeutig protektiven Effekt im Hinblick auf die StreB-Blutung, Anzahl und Schweregrad der StreB-Lasionen. Summary Twenty-two severely ill patients with multinle injuries and sepsis were treated with IV pirenzepin or placebo 3 x 10 mg per day in the frame of the double-blind study. All the patients were examined three times with endoscopy during the 14-day ob­ servation period. In 100% of cases without prophylactic treat­ ment, stress lesions were observed, 60% of these cases had bleeding. A prophylactic IV pirenzepin application had an un­ mistakable protective effect regarding the stress bleeding, number and degree of stress lesions. Literatur 1. BRODIE, D.A.: Experimental peptic ulcer. Gastroenterology 55, 125-134 (1968) 2. EINIG, D.: Ein neuer Sekretionshemmer. Ergebnisse einer Wir­ kungs- und Vertraglichkeitsprufung mit Gastrozepin. Therapie­ woche 27,1630-1638 (1977) 3. HASTINGS, P.R., SKILLMAN, J.J., BUSHNELL, L.J. et al.: Antacid titration in the prevention of acute gastrointestinal bleeding: a controlled randomized trial in 100 critically ill patients.

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