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Celowanie w cytoplazmatyczne kinazy tyrozynowe w raku

Celowanie w cytoplazmatyczne kinazy tyrozynowe w raku

Ahmed Abd EL-kader

36,62 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Química física
ISBN:
9786209288777
36,62 €
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Kinazy białkowe są kluczowymi regulatorami sygnalizacji komórkowej i stanowią jedną z najbardziej obiecujących grup celów terapeutycznych w onkologii. Wśród nich, cytoplazmatyczne kinazy tyrozynowe (CTK) odgrywają kluczową rolę w kontrolowaniu wzrostu, przeżycia i różnicowania komórek. Niniejszy przegląd przedstawia kompleksowy obraz CTK jako celów terapeutycznych, ze szczególnym uwzględnieniem kinazy c-Abl i jej onkogennego odpowiednika, Bcr-Abl, w przewlekłej białaczce szpikowej (CML). Znaczna część przeglądu poświęcona jest rozwojowi i ewolucji klinicznej inhibitorów Bcr-Abl, od leków pierwszej generacji konkurujących z ATP, takich jak imatynib, po leki drugiej i trzeciej generacji zaprojektowane w celu przezwyciężenia oporności. Na koniec omawiamy kliniczny krajobraz inhibitorów kinaz i perspektywy na przyszłość, przedstawiając historię Bcr-Abl jako paradygmat terapii celowanej w leczeniu raka.

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