Cancer Genome and Tumor Microenvironment

Part One: Opening remarks Hardwiring tumor progression (Andrei Thomas-Tikhonenko)Part Two: Breaking away: Epithelial-mesenchymal transition PI3K/AKT pathway and the epithelial-mesenchymal transition (Alfonso Bellacosa and Lionel Larue)Loss of cadherin-catenin adhesion system in invasive cancer cells (Wen-Hui Lien and Valeri Vasioukhin)Rho GTPases in regulation of cancer cell motility, invasion, and microenvironment (Donita Brady, Jamie Alan, and Adrienne Cox) Merlin/NF2 tumor suppressor and Ezrin-Radixin-Moesin (ERM) proteins in cancer development and progression (Ling Ren and Chand Khanna)Part Three: Coming up for air: Hypoxia and Angiogenesisvon Hippel-Lindau tumor suppressor, hypoxia-induced factor-1, and tumor vascularization (Huafeng Zhang and Gregg Semenza)RAS oncogenes and tumor-vascular interface (Janusz Rak)Myc and control of tumor neovascularization (Prema Sundaram, Chi V. Dang, and Andrei Thomas-Tikhonenko)p53 and angiogenesis (Jose Teodoro, Sara Evans, and Michael Green)Ink4a locus: beyond cell cycle (Gregory Enders)Part Four: Gaining new ground: Metastasis and stromal cell interactions NM23 as a metastasis inhibitor (Rajeev Kaul, Masanao Murakami, Pankaj Kumar, and Erle Robertson) HGF/c-MET signaling in advanced cancers (Mandira Ray, JG Garcia, and Ravi Salgia)Contribution of ADAMs and ADAMTSs to tumor expansion and metastasis (Antoni Xavier Torres-Collado and Luisa Iruela-Arispe) Stromal cells & tumor milieu: PDGF et al (Michele Jacob and Ellen Puré)Tgf-beta signaling alterations in neoplastic and stromal cells (Qinghua Zeng and Boris Pasche)Part Five: Getting attention: Immunerecognition and inflammationGenetic Instability and Chronic Inflammation in Gastrointestinal Cancers (Antonia Sepulveda and John Lynch)Immunoglobulin gene rearrangements, oncogenic translocations, B-cell receptor signaling, and B-lymphomagenesis (Murali Gururajan and Subbarao Bondada)Modulation of Philadelphia chromosome-positive hematological malignancies by bone marrow microenvironment (Lin Wang, Heather O’Leary, and Laura Gibson)Part 6: Putting it all togetherMelanoma: mutations in multiple pathways at the tumor-stroma interface (Himabindu Gaddipati and Meenhard Herlyn)Cooperation and Cancer (Kathleen Sprouffske and Carlo Maley, Wistar Institute)