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ForewordJudith Paice, RN, PhD, Northwestern University/ President of the American Pain SocietyForwardRichard M. Hirshberg, MD, (retired), Neurosurgery Department, St. Joseph’s Hospital, Houston, TXIntroduction: The challenge of pain and suffering in the global contextRhonda Moore, PhD, NCIChapter 1. Acute versus Chronic Pain: what are the differences?Lance McCracken, PhD, Kevin Vowels, PhD, University of Bath, UK Chapter 2. The Neuroanatomy of Pain and Pain Pathways Elie Al-Chaer, PhD, JD, University of Arkansas Medical School, USA Chapter 3. Genetics of chronic pain Alex MacGregor, MD, University of Norwich, UK Chapter 4. Pain and the Placebo Effect Antonella Pollo, MD, Fabrizio Benedetti, MD, The University of Turin, ItalyChapter 5. Narrative approaches to understanding the meaning of the pain experience Howard Spiro, MD, Yale University of MedicineChapter 6. Psychosocial and Partner-Assisted Approaches to the Management of PainFrank Keefe, PhD, Duke University and the Duke University Cancer CenterChapter 7. Sex Differences in Pain Perception Ed Keogh, PhD, University of Bath, UK Chapter 8. Children and Pain Giovanni Cucchiaro, MD, Children’s Hospital of Philadelphia (CHOP) Chapter 9. Pain in Older People Bill McCarberg, MD, Kaiser Permanente, CA, Barry Cole, MD, American Society for Pain EducatorsChapter 12. Pharmacoeconomics: economic and social costs of pain Rebecca Robinson, MS, Eli Lilly and Company; and Thomas Vetter, MD, MPH, University of Alabama School of Medicine, Birmingham, ALChapter 13. Chemotherapy induced peripheral neuropathies (CIPN): A biobehavioral approach Rhonda Moore, PhD (National Cancer Institute, NIHChapter 14. Pain in Patients with HIV: role of health services research Aram Dobalian, PhD, JD,Jennie C.I. Tsao,PhD and Lonnie K. Zeltzer, MD, University of California-Los Angeles Chapter 15. Pain Assessment, treatment and evaluationSydney Dy, MD, Johns Hopkins School of Medicine and the Johns Hopkins School of Public Health Chapter 16. Phantom Limb Pain Jan Geertzen, MD, PhD, Pieter Dijkstra, PT, PhD, the Department of Rehabilitation, University Hospital Groningen, NetherlandsChapter 17. Substance Abuse issues in the treatment of Pain PatientsArthur Lipman, Pharm D, The University of Utah; Howard Heit, MD, Virginia Chapter 18. Uses of Complementary and Alternative Medicine for Pain Catherine Stoney, PhD; Patrick Mansky, MD, The National Center for Complementary and Alternative Medicine (NCCAM), The National Institutes of Health, , Bethesda, MD Chapter 19. Imaging modalities for pain Dagfinn Matre, PhD, National Institute of Occupational Health, Norway; Tuan Diep Tran, MD, University of Medicine and Pharmacology, Ho Chi Mihn City, VietnamChapter 20. Pain, Whiplash Disorder and Traffic Safety: A Biobehavioural ApproachMichelle Sterling, PT, PhD, The University of Queensland, Australia Chapter 21. Gene Therapies for Pain William Lariviere, PhD, Doris Cope, MD, U of PittsburghChapter 22. Pain and Palliative Care Jim Hallenbeck, MD, Shana McDaniel, MS, Stanford Medical School and the VA-Palo Alto, CAChapter 23. Pain in Society: ethical perspectives and Public Policy Concerns