Badania dotyczące przygotowania i oceny mikrosfer cefiksymu

Badania dotyczące przygotowania i oceny mikrosfer cefiksymu

Mallikarjun Vasam

65,61 €
IVA incluido
Disponible
Editorial:
KS OmniScriptum Publishing
Año de edición:
2026
ISBN:
9786209579325
65,61 €
IVA incluido
Disponible

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Sobre IBD

Mikrosfery cefiksymu zostały opracowane w celu przezwyciężenia wad i wyeliminowania skutków ubocznych cefiksymu w konwencjonalnych postaciach dawkowania. Mikrosfery zostały opracowane przy użyciu alginianu sodu (3%, 4% i 5%) z kopolimerem Carbopol P934 i HPMC K15M w stężeniu 1% oraz chlorku wapnia (3%) jako środka sieciującego, przy użyciu techniki żelowania jonowego z otworem. Receptura mikrosfer opiera się na interakcji między polimerem a środkiem sieciującym. Alginian sodu jest polimerem anionowym, który można łatwo usieciować za pomocą chlorku wapnia, tworząc kompleks między jonem Ca+2 a alginianem sodu, co opóźnia uwalnianie leku. Wielkość cząstek scharakteryzowano za pomocą skaningowego mikroskopu elektronowego (SEM), a zgodność substancji pomocniczych leku określono za pomocą spektroskopii FTIR. Przeprowadzono również badania dotyczące procentowej zawartości leku, skuteczności uwięzienia, właściwości przepływowych, wskaźnika pęcznienia oraz uwalniania leku in vitro. Niniejsza książka zawiera szczegółowe informacje na temat przygotowania i badań oceniających mikrosfery.

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