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Activité non cytotoxique du venin de B. jararacussu

Activité non cytotoxique du venin de B. jararacussu

José Vitelio Ruiz Rivero

73,58 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Música
ISBN:
9786206835486
73,58 €
IVA incluido
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Les venins d’ophidiens sont des ressources biologiques d’une grande valeur pharmacologique. Outre le petit nombre de médicaments antiviraux, de nombreux agents pathogènes développent des mécanismes pour échapper à l’action des médicaments, ce qui entraîne des taux de résistance croissants. Il a été démontré que les biomolécules contenues dans les venins d’ophidiens ont une grande valeur thérapeutique et pourraient être utilisées comme agents antimicrobiens. L’objectif de ce travail est d’évaluer l’activité non cytotoxique du venin brut isolé de Bothrops jararacussu dans les cellules mononucléaires du sang périphérique. Dans cette étude, des cellules mononucléaires de donneurs sains ont été séparées. Après avoir activé les cellules avec de la phytohémagglutinine et de l’interleukine-2, différentes concentrations de venin ont été ajoutées pour évaluer son activité non cytotoxique. Cette étude ouvre la voie à de nouvelles recherches visant à identifier les activités antimicrobiennes des venins bruts et de leurs fractions.

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