Librería Samer Atenea
Librería Aciertas (Toledo)
Kálamo Books
Librería Perelló (Valencia)
Librería Elías (Asturias)
Donde los libros
Librería Kolima (Madrid)
Librería Proteo (Málaga)
Several concerns about the effects of the combination of human chemical exposure with the stressful conditions of the Gulf War have been raised. The wartime stress experienced by soldiers can vary from physical to mental and emotional stress. Each type of stress causes changes in the human body, including blood flow, hormonal, and ventilation changes, and may increase the permeability of the blood-brain barrier. Each change influences the chemical uptake, distribution, and accumulation in the body. The purpose of this thesis was to model and predict the changes that occur when stress and exercise are combined with chemical exposure. A Physiologically-based pharmacokinetic (PBPK) model was used as a tool to visualize, predict, and generate a hypothesis about chemical exposures. The PBPK model developed simulated human tissue compartments during chemical exposure under varying stress and exercise conditions. As a result of the system dynamics process, the PBPK model developed may be a valid tool for helping to explain and predict the fate and transport of a chemical on an individual under the physical stress of exercise, and other less-defined stressors which directly affect the blood-brain barrier transport mechanisms in the model. The results suggest that the chemical concentrations in the brain are highly dependent on the transport mechanisms involved. The transport mechanisms and their respective strengths have been identified as key parameters for further study. The model developed is a simple tool that can be applied to future exploration.This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
