LIBROS DEL AUTOR: rui kamada

1 resultados para LIBROS DEL AUTOR: rui kamada

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  • Tetramer Stability and Functional Regulation of Tumor Suppressor Protein p53
    Rui Kamada
    This thesis presents the first report of the comprehensive and quantitative analysis of the effects of tumor-derived mutations on the tetrameric structure of tumor suppressor protein p53, which plays a central role in maintaining genomic integrity. Inactivation of p53 via mutation of its gene is a key step in tumorigenesis. Biophysical analyses revealed that the stability of th...
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