LIBROS DEL AUTOR: laware ravindra

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  • Solubility enhancement by Solid Dispersion Technique
    Laware Ravindra / Narkhede Kantilal / Narkhede Sachin
    Bicalutamide is poorly soluble drug which is non-steroidal androgen having pKa 12. Aqueous in vitro solubility of bicalutamide is low at 50 μg/mL at pH 7 and 37°C. The drug exhibits low bioavailability related to its poor water solubility. Therefore, bicalutamide bioavailability can be improved by increasing its solubility. Solid dispersion technique is most effective technique...
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