LIBROS DEL AUTOR: ali osman konuray

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  • Development of Tolerance and Dependence in Barbiturate Use
    Ali Osman Konuray
    A mathematical model is constructed to study the development of tolerance and dependence to phenobarbital in continuous use. Phenobarbital is a sedative drug targeting the brain. As a side effect, it enhances its own metabolism rate. Also in regular use, the brain adapts to its presence and is rendered less sensitive to the drug with time. This decrease in drug effectiveness ur...
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