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Gramnegative Bacilli, die aus der Krankenhausumgebung isoliert wurden

Gramnegative Bacilli, die aus der Krankenhausumgebung isoliert wurden

Abdelbasset Mechai / Manel Debabza

131,24 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Microbiología (no médica)
ISBN:
9786207044139
131,24 €
IVA incluido
Disponible

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Bei dieser Untersuchung wurden 306 Stämme gramnegativer Bazillen (BGN) aus der Krankenhausumgebung isoliert, darunter 74,51% Enterobakterien. Die Untersuchung der Antibiotikaempfindlichkeit zeigte eine Resistenz gegen verschiedene Familien, insbesondere gegen β-Laktam-Antibiotika, wobei jedoch Imipenem, Aminoglykoside und Fluorchinolone bemerkenswert wirksam waren. Durch Tests auf Extended-Spectrum-Beta-Laktamasen (ESBL) wurden 114 Stämme von ESBL-produzierenden Enterobakterien (EBLSE) charakterisiert. Die Analyse der Plasmidprofile zeigte, dass die multiresistenten Stämme 1 bis 4 Plasmide von 1Kb bis 170Kb beherbergen. Konjugationsexperimente zeigten die Mitübertragung der Resistenz gegen Gentamicin und Cotrimoxazol auf Plasmide mit 10Kb, 20Kb, 125Kb oder 165Kb. Durch die PCR der transkonjugierenden Stämme konnten die Gene bla CTX-M-1, bla TEM und bla SHV sowie die qnrB-Gene nachgewiesen werden. Diese Studie zeigt, dass die Krankenhausumgebung mit multiresistenten BGN, insbesondere EBLSE, kontaminiert ist und eine potenzielle Quelle für Epidemien sein kann, was dazu veranlasst, Empfehlungen innerhalb der Gesundheitsstrukturen vorzuschlagen.

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Otros libros del autor

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    In this study, 306 Gram-negative bacilli (GNB) strains were isolated from the hospital environment, 74.51% of them enterobacteria. Antibiotic susceptibility testing revealed resistance to various families of antibiotics, in particular β-lactam antibiotics, although imipenem, aminoglycosides and fluoroquinolones were remarkably effective. Extended-spectrum beta-lactamase (ESBL) ...
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    Neste estudo, foram isoladas 306 estirpes de bacilos Gram-negativos (BGN) do ambiente hospitalar, 74,51% das quais eram enterobactérias. Os testes de suscetibilidade aos antibióticos revelaram resistência a várias famílias de antibióticos, particularmente aos antibióticos β-lactâmicos, embora o imipenem, os aminoglicosídeos e as fluoroquinolonas tenham sido notavelmente eficaze...
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