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Biologia del liquor e diagnosi di sclerosi multipla

Biologia del liquor e diagnosi di sclerosi multipla

Mariem DAMMAK / Sabrina MEJDOUB / Sawsan FEKI

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Biologia, ciencias de la vida
ISBN:
9786207180721

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Attraverso la nostra esperienza, abbiamo analizzato il valore dell’esplorazione immunologica, ovvero il calcolo dell’indice IgG e l’isoelettrofocalizzazione (IEF) nella rilevazione delle IgG IS per la diagnosi di sclerosi multipla (SM), una malattia infiammatoria cronica demielinizzante del sistema nervoso centrale (SNC). A tal fine, abbiamo condotto uno studio che ha coinvolto 223 pazienti con sospetta SM per i quali è stato richiesto un test immunologico del liquor. Vi erano 2 gruppi di pazienti: 'SM' (n=54) e 'non SM' (n=96). L’indice IgG era ≥ 0,7 in 43/53 dei pazienti con 'SM' e in 15/94 dei pazienti 'non SM'. Per l’IEF, questa tecnica ha mostrato un profilo 2 o 3 (bande oligoclonali (BOC)+) in 51/54 casi di 'SM'. Nei pazienti non SM, l’IEF ha mostrato un profilo 1 o 4 in 75 casi e un profilo (BOC+) in 21 casi. La sensibilità e la specificità per la diagnosi di SM sono state rispettivamente dell’81%-84% per l’indice IgG e del 94%-81% per l’IEF. In conclusione, i nostri risultati hanno dimostrato che l’IEF nel liquor è il test più sensibile per rilevare l’IS IgG e costituisce il 'gold standard' nell’indagine biologica della SM.

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